Prof. Ian Gilmore is Head of Science at the National Physical Laboratory (NPL), Senior NPL Fellow and a Visiting Professor in the School of Pharmacy at the University of Nottingham. He is founding director of the UK’s National Centre of Excellence in Mass Spectrometry (NiCE-MSI). Ian’s research goal is to achieve super-resolution label-free metabolic imaging. He has a special interest in reducing drug attrition through measuring where drugs go and their pharmacological effect at a sub-cellular scale.
To study this, he created the revolutionary 3D OrbiSIMS (Nature Methods 2017) in collaboration with GlaxoSmithKline. His research interests also include 3D molecular imaging of complex interfaces in organic electronics, batteries and additive manufactured devices using OrbiSIMS and FIB-SIMS.
Ian has over 25 years’ experience in mass spectrometry of surfaces and has published more than 140 peer-reviewed papers. He is a consultant and advisor to a number of companies, including GlaxoSmithKline and Samsung. He was awarded the IoP Paterson medal (2004) and the UKSAF Riviere prize (2013) for a major contribution to international leadership in surface analysis.
Ian leads international standardisation in surface chemical analysis and is chair of ISO TC 201 SC 6 (Mass Spectrometry) and chair of VAMAS TWA 2. He is championing the topic of reproducibility in research and has recently published on this topic (Nature 2017, JVST A 2018 , NIST Journal Research 2019).
Selected recent research papers
- The 3D OrbiSIMS—label-free metabolic imaging with subcellular lateral resolution and high mass resolving power, M Passarelli, A Pirkl, R Moellers, D Grinfeld, F Kollmer, R Havelund, C F Newman, P S Marshall, H Arlinghaus, M Alexander, A West, S Horning, E Niehuis, A Makarov, C Dollery, I Gilmore, Nature methods 14 , 1175 2017
- Single-cell Analysis: Visualizing Pharmaceutical and Metabolite Uptake in Cells with Label-free 3D Mass Spectrometry Imaging, M Passarelli, CJ Newman, PS Marshall, A West, IS Gilmore, J Bunch, M Alexander, C T Dollery, Anal. Chem., 87 , 6696 2015
- Chemical intervention in plant sugar signalling increases yield and resilience, C A Griffiths, R Sagar, Y Geng, L F Primavesi, M K Patel, M K Passarelli, I S Gilmore, R T Steven, J Bunch, M J Paul, B G Davis, Nature 540 , 574 2016.
- High-resolution sub-cellular imaging by correlative NanoSIMS and electron microscopy of amiodarone internalisation by lung macrophages as the evidence for drug-induced phospholipidosis. H Jiang, M Passarelli, P Munro, M Kilburn, A West, C Dollery, I Gilmore, P Rakowska, Chem Comm. 53, 1506 2017.
- Intracellular Drug Uptake: A Comparison of Single Cell Measurements Using ToF-SIMS Imaging and Quantification from Cell Populations with LC/MS/MS, C Newman, R Havelund, M Passarelli, P Marshall, I Francis, A West, M Alexander, I Gilmore, C Dollery, Anal. chemistry 89, 11944 2017
Selected recent reviews and teaching material
- Surface analysis: The principal techniques, Eds J.C.Vickerman and I. S. Gilmore, Wiley (2011)
- Metabolic imaging at the single-cell scale: recent advances in mass spectrometry imaging, Ian S Gilmore, Sven Heiles, Cornelius L Pieterse, Annual Rev. Anal. Chem. 12, 201 2019.
- Responding to the growing issue of research reproducibility, D. R. Baer and I. S. Gilmore, J. Vac. Sci. Tech. A 36, 068502 2018.
- Improving Reproducibility in Research: The Role of Measurement Science, R. J. Hanisch, I. S Gilmore, A. L. Plant, J. Res. NIST 124, 1 2019.
- Metrology is key to reproducing results”, M Sene, I Gilmore, JT Janssen, Nature 547, 397, 2017
For all publications see: