Creating a toolbox of reference materials and methods to drive translation in EngBio

There are many variables to consider in engineering biology processes. Referencing processes and inputs to to agreed standards to helps provide confidence in manufacturing consistency and the ability to measure and control key performance parameters. These are key attributes in deciding which products and processes are adopted and commercialised.

NPL’s engineering biology research and development programmes are addressing specific measurement challenges faced by industry. We are developing a toolbox of reference materials and methods, calibrants, cells, documented standards and best-practice guides.

Virtual institute

Initial investment through The Industrial Strategy Challenge Fund enabled the development of a virtual institute established by NPL and partners. This included other National Measurement System organisations, LGC and National Institute for Biological Standards and Control, along with SynbiCITE at Imperial College London.

Building a measurement framework to underpin growth in engineering biology

In response to the metrology challenges presented by engineering biology, NPL are establishing a measurement framework for engineering biology to support a bottom-up approach to control bio-manufacturing processes, both in-cellulo (intracellular) and in-vitro (cell-free). A framework approach, built upon the principles of modularisation which defines biological parts as molecular units of biological activity that can be more effectively and repeatably delivered enables assembly into systems or devices. Modularisation applies across all scales of engineering biology including nucleic acids, cells, cell-free systems and protein assemblies. Each of these can serve as a functional component or product within an engineering biology process requiring improved standardisation.

Si-traceable reference standards to support EngBio innovation

Nanoscale and cell rulers