Mike is a Principal Scientist in the Biometrology group at NPL where he leads the development and application of high-resolution optical microscopy techniques for bioimaging. Mike is a Chartered Physicist and also holds a part-time position in the Department of Computer Science at University College London.
Mike joined NPL in 2001 after completing an MSci in Physics at Imperial College London. His early work concerned the development of methods and instrumentation for measuring the optical properties of materials (scattering and fluorescence) and light sources (spectroradiometry). Mike continued his research in applied optics by working on metrological techniques for adaptive optics and high-resolution imaging, during which time he completed his PhD, titled 'Overcoming resolution limits in fluorescence microscopy with adaptive optics and structured illumination'.
Since joining NPL's Biometrology group in 2010 his primary research focus has been the development of optical microscopy systems and related techniques for quantitative imaging of biological systems from peptides and proteins to cells and tissues. He works with a multidisciplinary team of scientists to apply these techniques to a range of measurement challenges in the life sciences and beyond.
- Visualisation and quantitative imaging of biological systems
- Super-resolution structured illumination microscopy (SIM), light sheet microscopy, computational microscopy (light field and ptychographic techniques)
- Imaging of live cells and dynamic systems
- Image processing and analysis
- Microscope calibration and standardisation
- Optical mesoscopy, machine learning and computational microscopy enable high information content diagnostic imaging of blood films, Shaw, M. et al., J. Pathol. 255, 62-71, 2021
- Three-dimensional behavioural phenotyping of freely moving C. elegans using quantitative light field microscopy, Shaw, M. et al., Plos one 13 (7), e0200108, 2018
- CREIM: Coffee Ring Effect Imaging Model for Monitoring Protein Self-Assembly in Situ, Shaw, M. et al, J. Phys. Chem. Lett, 8 (19), 4846-4851, 2017
- Optimized approaches for optical sectioning and resolution enhancement in 2D structured illumination microscopy, O’Holleran, K. & Shaw, M., Biomed. Opt. Express 5 (8), 2580-2590, 2014