This project has resulted in increased experience of MRI multi-site studies and strengthened strategic collaborations within the UK. This has led to a better understanding of how reproducible and reliable tissue images of tissue microstructure are when measured by different teams at different sites. It is also the first deployment of new advanced diffusion phantoms in a study of this kind, and the first to compare phantom and human data of these advanced methods in a multi-site context.
The work aims to provide quantitative estimates of the structure of brain tissue from image data only and have huge potential for diagnosing and monitoring diseases such as cancer and dementia. Translation of these techniques into clinical environments would provide significantly more information to clinicians and patients than is available from conventional scans, improving medical judgements and personalising treatment and prognosis.
Knowledge of reproducibility also impacts clinical trial design. Broader participation in advanced imaging means that existing scanning infrastructure can be used more effectively, and that researchers can be more confident in their conclusions. Obtaining and using more information from each study participant reduces study costs and allows applications in more diseases than is currently possible.