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OrbiSIMS

OrbiSIMS global bibliography

We are accurately mapping and measuring the chemical composition for metabolic profiling of biological samples.

Find out about the latest OrbiSIMS-related research around the world

If you would like to find out more or add your publications to these pages please contact us.

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OrbiSIMS publications

  • Aoyagi, Satoka, et al. "Quantitative and Qualitative Analyses of Mass Spectra of OEL Materials by Artificial Neural Network and Interface Evaluation: Results from a VAMAS Interlaboratory Study." Analytical Chemistry (2023).
  • Suvannapruk, Waraporn, et al. "Spatially resolved molecular analysis of host response to medical device implantation using the 3D OrbiSIMS." bioRxiv (2023): 2023-08.
  • Suvannapruk, Waraporn, et al. "Label-free Chemical Characterization of Polarized Immune Cells in vitro and Host Response to Implanted Bio-instructive Polymers in vivo Using 3D OrbiSIMS." Bio-protocol 13.15 (2023).
  • Kern, Christine, et al. "Secondary ion mass spectrometry for bone research." Biointerphases 18.4 (2023).
  • Linke, Franziska, et al. “Identifying new biomarkers of aggressive Group 3 and SHH medulloblastoma using 3D hydrogel models, single cell RNA sequencing and 3D OrbiSIMS imaging.” Acta Neuropathologica Communications (2023)
  • He, Wenshi, et al. "Untargeted Metabolomic Characterization of Glioblastoma Intra-Tumor Heterogeneity Using OrbiSIMS." Analytical Chemistry (2023).
  • Songtao, Xue, et al. “Design, Synthesis, and Biological Evaluation of Novel Hybrids Containing Dihydrochalcone as Tyrosinase Inhibitors to Treat Skin Hyperpigmentation” Journal of Medicinal Chemistry (2023).
  • Khateb, Heba, et al. "Identification of Pseudomonas aeruginosa exopolysaccharide Psl in biofilms using 3D OrbiSIMS." Biointerphases 18.3 (2023).
  • Shon, Hyun Kyong, et al. "Comparison study of mouse brain tissue by using ToF-SIMS within static limits and hybrid SIMS beyond static limits (dynamic mode)." Biointerphases 18.3 (2023).
  • Jeong, Yeonsu, et al. "Observing the Distribution of Intact Molecules in Multi-Layer Organic Solar Cells Using Orbisims." Available at SSRN 4427515.
  • Hook, Andrew, and Holger Wondraczek. "Secondary ion mass spectrometry analysis of pentosan polysulfate." Available at SSRN 4384834 (2023).
  • Zani, Fabio, et al. "The dietary sweetener sucralose is a negative modulator of T cell-mediated responses." Nature (2023): 1-7.
  • Vassey, Matthew, et al. "Innate immune cell instruction using micron-scale 3D objects of varied architecture and polymer chemistry: The ChemoArchiChip." Matter (2023).
  • Linke, Franziska, et al. "Identifying new biomarkers of aggressive Group 3 and SHH medulloblastoma using 3D hydrogel models, single cell RNA sequencing and 3D OrbiSIMS imaging." Acta Neuropathologica Communications 11.1 (2023): 1-18.
  • Im, Jisun, et al. "Strategies for Integrating Metal Nanoparticles with Two‐Photon Polymerization Process: Toward High Resolution Functional Additive Manufacturing." Advanced Functional Materials (2023): 2211920.
  • Muresan, Paula, et al. "Development of nanoparticle loaded microneedles for drug delivery to a brain tumour resection site." European Journal of Pharmaceutics and Biopharmaceutics 182 (2023): 53-61.
  • Kern, Christine, et al. "Characterisation of Sr 2+ mobility in osteoporotic rat bone marrow by cryo-ToF-SIMS and cryo-OrbiSIMS." Analyst 147.18 (2022): 4141-4157.
  • Edney, Max K., et al. "Time resolved growth of (N)-polycyclic aromatic hydrocarbons in engine deposits uncovered with OrbiSIMS depth profiling." Analyst 147.17 (2022): 3854-3866.
  • Edney, Max K., et al. "Molecular formula prediction for chemical filtering of 3D OrbiSIMS Datasets." Analytical Chemistry 94.11 (2022): 4703-4711.
  • Matjacic, Lidija, et al. "OrbiSIMS metrology Part I: Optimisation of the target potential and collision cell pressure." Surface and Interface Analysis 54.4 (2022): 331-340.
  • Suvannapruk, Waraporn, et al. "Single-Cell Metabolic Profiling of Macrophages Using 3D OrbiSIMS: Correlations with Phenotype." Analytical Chemistry 94.26 (2022): 9389-9398.
  • McCrorie, Phoebe, et al. "Detection of Label-Free Drugs within Brain Tissue Using Orbitrap Secondary Ion Mass Spectrometry as a Complement to Neuro-Oncological Drug Delivery." Pharmaceutics 14.3 (2022): 571.
  • Dundas, Adam A., et al. "A new particle mounting method for surface analysis." Surface and Interface Analysis 54.4 (2022): 374-380.
  • Starr, Nichola J., et al. "Elucidating the molecular landscape of the stratum corneum." Proceedings of the National Academy of Sciences 119.12 (2022): e2114380119.
  • Johnson, James, et al. "MEDB-24. Tumour secreted extracellular matrix predicts survival and influences migration and cell death in SHH medulloblastoma 3D models." Neuro-Oncology 24.Suppl 1 (2022): i110.
  • Franquet, A., et al. "Orbitrap™-SIMS analysis of advanced semiconductor inorganic structures." Vacuum 202 (2022): 111182.
  • Im, Jisun, et al. "Functionalized Gold Nanoparticles with a Cohesion Enhancer for Robust Flexible Electrodes." ACS Applied Nano Materials 5.5 (2022): 6708-6716.
  • Spampinato, Valentina, et al. "SIMS analysis of thin EUV photoresist films." Analytical Chemistry 94.5 (2022): 2408-2415.
  • Webb, Thomas, et al. "A Multifaceted Ferrocene Interlayer for Highly Stable and Efficient Lithium Doped Spiro‐OMeTAD‐based Perovskite Solar Cells." Advanced Energy Materials 12.26 (2022): 2200666.
  • Watson, Rowan, et al. "Efficacy of antimicrobial and anti-viral coated air filters to prevent the spread of airborne pathogens." Scientific Reports 12.1 (2022): 2803.
  • Franquet, A., et al. "Orbitrap™-SIMS analysis of advanced semiconductor inorganic structures." Vacuum 202 (2022): 111182.
  • Hu, Qin, et al. "The influence of printing parameters on multi-material two-photon polymerisation based micro additive manufacturing." Additive Manufacturing 51 (2022): 102575.
  • Bryant, Jack A., et al. "Developing Novel Biointerfaces: Using Chlorhexidine Surface Attachment as a Method for Creating Anti‐Fungal Surfaces." Global Challenges 6.5 (2022): 2100138.
  • Simões, Bárbara, et al. "Direct immobilization of engineered nanobodies on gold sensors." ACS Applied Materials & Interfaces 13.15 (2021): 17353-17360.
  • Hodgkinson, Tom, et al. "The use of nanovibration to discover specific and potent bioactive metabolites that stimulate osteogenic differentiation in mesenchymal stem cells." Science Advances 7.9 (2021): eabb7921.
  • Trindade, Gustavo F., et al. "Residual polymer stabiliser causes anisotropic electrical conductivity during inkjet printing of metal nanoparticles." Communications Materials 2.1 (2021): 47.
  • Ruiz-Cantu, Laura, et al. "Bespoke 3D-Printed Polydrug Implants Created via Microstructural Control of Oligomers." ACS Applied Materials & Interfaces 13.33 (2021): 38969-38978.
  • Wang, Feiran, et al. "Inter‐flake quantum transport of electrons and holes in inkjet‐printed graphene devices." Advanced Functional Materials 31.5 (2021): 2007478.
  • He, Yinfeng, et al. "Exploiting generative design for 3D printing of bacterial biofilm resistant composite devices." Advanced Science 8.15 (2021): 2100249.
  • Meurs, Joris, et al. "Sequential orbitrap secondary ion mass spectrometry and liquid extraction surface analysis-tandem mass spectrometry-based metabolomics for prediction of brain tumor relapse from sample-limited primary tissue archives." Analytical Chemistry 93.18 (2021): 6947-6954.
  • Lamb, Joseph S., et al. "Internal Diesel Injector Deposit Chemical Speciation and Quantification Using 3D OrbiSIMS and XPS Depth Profiling." SAE International Journal of Advances and Current Practices in Mobility 3.2020-01-2098 (2020): 349-364.
  • Vassey, Matthew J., et al. "Immune modulation by design: using topography to control human monocyte attachment and macrophage differentiation." Advanced Science 7.11 (2020): 1903392.
  • Hammann, Simon, et al. "Mechanisms of lipid preservation in archaeological clay ceramics revealed by mass spectrometry imaging." Proceedings of the National Academy of Sciences 117.26 (2020): 14688-14693.
  • Edney, Max K., et al. "Spatially resolved molecular compositions of insoluble multilayer deposits responsible for increased pollution from internal combustion engines." ACS Applied Materials & Interfaces 12.45 (2020): 51026-51035.
  • Kotowska, Anna M., et al. "Protein identification by 3D OrbiSIMS to facilitate in situ imaging and depth profiling." Nature Communications 11.1 (2020): 5832.
  • Newell, Clare L., et al. "Cryogenic OrbiSIMS Localizes Semi‐Volatile Molecules in Biological Tissues." Angewandte Chemie International Edition 59.41 (2020): 18194-18200.
  • Zhang, Junting, et al. "Cryo-OrbiSIMS for 3D molecular imaging of a bacterial biofilm in its native state." Analytical Chemistry 92.13 (2020): 9008-9015.
  • Rowlinson, J., et al. "P11. 62 Brain distribution models to select polymer-delivered drugs for the intra-cavity treatment of malignant glioma." Neuro-oncology 21.Supplement_3 (2019): iii58-iii58.
  • Tiddia, Mariavitalia, et al. "Chemical Imaging of Buried Interfaces in Organic–Inorganic Devices Using Focused Ion Beam-Time-of-Flight-Secondary-Ion Mass Spectrometry." ACS applied materials & interfaces 11.4 (2019): 4500-4506.
  • Aoyagi, Satoka, et al. "OrbiSIMS imaging identifies molecular constituents of the perialgal vacuole membrane of Paramecium bursaria with symbiotic Chlorella variabilis." Analytical chemistry 91.22 (2019): 14545-14551.
  • Gilmore, I. S. "Metabolic imaging at the single-cell scale–recent advances and future challenges in mass spectrometry imaging." Journal of Surface Analysis 26.2 (2019): 174-175.
  • Passarelli, Melissa K., et al. "The 3D OrbiSIMS—label-free metabolic imaging with subcellular lateral resolution and high mass-resolving power." Nature methods 14.12 (2017): 1175-1183.

OrbiSIMS theses and dissertations

  1. Thornton, Luke. Investigating the role of eIF4A2 in the spatial regulation of metabolic adaptation to hypoxia in colorectal cancer. Diss. University of Nottingham.
     
  2. Li, Zhiwei. Development of existing and novel tyrosinase inhibitors for skin pigmentation: intradermal delivery, biological evaluation and mechanistic studies. Diss. University of Nottingham, 2023.
     
  3. He, Wenshi. Surface Mass Spectrometry for in situ Metabolomic Analysis of Human Brain Tumours. Diss. University of Nottingham, 2023.
     
  4. Chauhan, Veeren. Development of Bioinformatic Methods to Determine Chemical Differences Between Nematode Species. Diss. University of Nottingham.
     
  5. Edney, Max. Uncovering the molecular compositions, origins and formation pathways of engine deposits using OrbiSIMS. Diss. University of Nottingham, 2022.
     
  6. Lamb, Joseph. Advanced characterisation of internal diesel injector deposit molecular compositions. Diss. University of Nottingham, 2022.
     
  7. Kotowska, Anna. Enabling in situ protein analysis for pharmaceutical applications using 3D OrbiSIMS. Diss. University of Nottingham, 2022.
     
  8. Chauhan, Veeren. Development of Bioinformatic Methods to Determine Chemical Differences Between Nematode Species. Diss. University of Nottingham.

9. Jewell, Adelaide. Targeted bio-distribution of drugs to the lymphatic system. Diss. University of Nottingham, 2022.​

10. Edney, Max. Uncovering the molecular compositions, origins and formation pathways of engine deposits using OrbiSIMS. Diss. University of Nottingham, 2022.

11. Lamb, Joseph. Advanced characterisation of internal diesel injector deposit molecular compositions. Diss. University of Nottingham, 2022.

12. Newell, Clare Laura Louise. Mass Spectrometry and Genetic Analysis of Biological Barrier Lipids. Diss. UCL (University College London), 2021.

13. Webb, Thomas. Organometallocenes for high performance perovskite solar cells. Diss. University of Surrey, 2021.

14. Meurs, Joris. "Sequential 3D OrbiSIMS and LESA-MS/MS-based metabolomics for prediction of brain tumor relapse from sample-limited primary tissue archives." (2021).

15. McCrorie, Phoebe. Developing a sprayable drug delivery system for the local delivery of nanoparticles in glioblastoma multiforme. Diss. University of Nottingham, 2021.

16. Newman, Carla AF. Probing the distribution of pharmaceutical compounds in cells using ToF-SIMS. Diss. University of Nottingham, 2019.

 

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