NPL offers expertise and a range of dosimetry measurements, from reference dosimetry to end-to-end audit of commercial and bespoke radiation units used in pre-clinical studies. These include broad-field, low-energy and medium-energy X-ray cabinets, bespoke shielding setups, clinical orthovoltage units and image-guided irradiators.
Contrary to clinical settings (where dose uncertainties associated with dose measurements are less than 3%), radiobiological experiments are typically affected by dose uncertainties of around 20% to 35%. These significant measurement uncertainty levels can hamper translational progress and demand higher number of experiments to be performed to establish for statistically significant data sets.
The need for standardisation and improved dosimetry for pre-clinical studies has been identified by researchers, funding agencies, journal editors and regulatory bodies, and is a priority of the Clinical and Translational Radiotherapy Research Working Group (CTRad). It was also addressed in the Integrity in Research POSTNote published by the Parliamentary Office of Science and Technology (POST).
NPL can help reduce the uncertainty associated with these types of pre-clinical dosimetry studies through:
Our research and measurement solutions support innovation and product development. We work with companies to deliver business advantage and commercial success. Contact our Customer Services team on +44 20 8943 7070