National Physical Laboratory

James Noble

James Noble

Current interests

Dr James Noble is leading work on applications in diagnostics and clinical chemistry with the aim to improve measurements of clinical biomarkers. He is working with the IFCC and NIST to develop standards and reference methods for the cardiac marker troponin I, used to diagnose myocardial infarction. He has an interest in multi-marker point of care assays in both the development of new technology and understanding the sources of error in the resulting measurements. He runs the biomolecular interaction measurement service at NPL with the main focus on Biacore SPR measurements for antibodies and small molecules. James also has an interest in self-assembled peptide structures for sensing, delivery and optical applications.

Biography

James received a BSc degree in medical biochemistry and an MSc degree in toxicology from the University of Birmingham, UK. In 2004 he received a PhD degree in Chemical Biology (Biosensors) from Imperial College London for research on enzymatic fluorescent biosensors for cellular screening applications. This work was in collaboration with Novartis and University College London. Since then he has worked at NPL in the Biotechnology team.

Selected publications

  • Rapid duplex immunoassay for wound biomarkers at the point-of-care
    G. J. Worsley, S. L. Attree, J. E. Noble, A. M. Horgan
    Biosens. Bioelectron. 34 (1), pages 215-20 (2012)
  • Point: Put simply, standardization of cardiac troponin I is complicated
    R. H. Christenson, D. M. Bunk, H. Schimmel, J. R. Tate
    IFCC Working Group on Standardization of Troponin I, Clin Chem. 58 (1), pages 165-8 (2012)
  • Bayesian analysis of an international ELISA comparability study
    K. Klauenberg, B. Ebert, J. Voigt, M. Walzel, J. E. Noble, A. E. Knight, C. Elster
    Clin Chem Lab Med. 49 (9), pages 1459-68 (2011)
  • The rational development of molecularly imprinted polymer-based sensors for protein detection
    M. J. Whitcombe, I. Chianella, L. Larcombe, S. A. Piletsky, J. Noble, R. Porter, A. Horgan
    Chem Soc Rev. 40 (3), pages 1547-71 (2011)
  • Development of a candidate secondary reference procedure (immunoassay based measurement procedure of higher metrological order) for cardiac troponin I: I. Antibody characterization and preliminary validation
    J. E. Noble, D. M. Bunk, R. H. Christenson, K. D. Cole, H. J. He, A. G. Katrukha, M. Panteghini, R. A. Porter, H. Schimmel, J. R. Tate, L. Wang
    IFCC Working Group on Standardization of Troponin I (WG-TNI), Clin Chem Lab Med. 48 (11), pages 1603-10 (2010)
  • Polymer- and colloid-mediated bioassays, sensors and diagnostics
    A. M. Horgan, J. D. Moore, J. E. Noble, G. Worsley
    J. Trends Biotechnol. 28 (9), pages 485-94 (2010)

Contact details

Email: james.noble@npl.co.uk
Tel: 020 8943 6927

Last Updated: 15 May 2013
Created: 26 Mar 2012

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