Current Interests

• Peptide design and synthesis
• Peptide folding and self-assembly
• Biophysical characterisation of biomolecules

Biography

After receiving her Master's degree in chemistry and pharmaceutical technology (La Sapienza, Rome), Emiliana de Santis moved to the UK where she completed her PhD in Chemistry from the University of Kent, studying the folding and metal binding ability of novel peptidomimetics. Emiliana pursued her interest in folding of biomolecules during post-doctoral studies at Diamond Light Source before joining NPL in 2013. Her current research focuses on applying protein design and biophysics to further the understanding of biomolecular self-assembly and its quantitative measurement.

Selected Publications

• Effect of capping groups at the N- and C-termini on the conformational preference of α,β-peptoids
  E. De Santis, T. Hjelmgaard, C. Caumes, S. Faure, B. D. Alexander, S. J. Holder, G. Siligardi, C. Taillefumier, A. A. Edwards
  Org. Biomol. Chem. 10, pages 1108-1122 (2012)
• Cyclic α,β-peptoid octamers with differing side chain patterns: synthesis and conformational investigation
  E. De Santis, T. Hjelmgaard, S. Faure, O. Roy, C. Didierjean, B. D. Alexander, G. Siligardi, R. Hussain, T. Ja´vorfi, A. A. Edwards, C. Taillefumier
  Amino Acids 41, pages 663–672 (2011)
• Exploiting CH-π interactions in supramolecular hydrogels of aromatic carbohydrate amphiphiles
  L. S. Birchall, S. Roy,V. Jayawarna, M. Hughes, E. Irvine,G. T. Okorogheye, N. Saudi, E. De Santis, T. Tuttle, A. A. Edwards, R. V. Ulijn
  Chem. Sci., 2, pages 1349-1355 (2011)

Contact details

Email: emiliana.de.santis@npl.co.uk
Tel: 020 8943 6165