Funded by the Innovate UK's Non-Animal Technologies programme, a dosimetry service has been established at the National Physical Laboratory to support the pre-clinical radiation research community and provide traceable dosimetry for X-ray cabinets and Image Guided Small Animal Irradiators.
The service is based on alanine dosimetry and traceable to UK primary standards and it uses a variety of phantoms mimicking conventional plastic-ware used for cell culture and an anatomically correct tissue equivalent mouse phantom (available through Leeds Test Objects. Precision of single dosimeter measurement is better than 1.5% at 1σ for doses >15 Gy
Mouse phantom components: skeleton made of 3D-printable Accura Bluestone, lungs made of PU330, soft tissues made of WT1
Maximum intensity projection from original mouse (left) and phantom (right).
Far right, CT image of phantom with alanine pellet inserted in skull. Alanine pellets in the top right insert