Drug delivery systems
polymer showing the localisation of drug
(green) in the polymer (blue) and salt
at the interface (red)
The controlled and targeted administration of drugs is extremely important to ensure that patients receive effective doses over the proper period and in the correct location. This requires extensive material design, which must be supported by appropriate measurement methods. In drug delivery systems, the distribution and concentration of active ingredients is critical to their correct operation. We are developing surface analytical measurement tools to address these issues in collaboration with the Pharmacy Department of the University of Nottingham.
Organic depth profiling has proven to be an extremely powerful tool in this regard and we are beginning to address some of the fundamental issues regarding the ability to determine drug concentrations using this novel approach.
Selected Publications
[1] Quantitative XPS Depth profiling of codeine loaded poly(L-lactide) films using a coronene ion sputter source, A Rafati, M C Davies, A G Shard, S Hutton, G Mishra, M R Alexander, J Contr Rel 138 (2009) 40
[2] Organic depth profiling of a binary system: the compositional effect on secondary ion yield and a model for charge transfer during secondary ion emission, A G Shard, A Rafati, R Ogaki, J L S Lee, S Hutton, G Mishra, M C Davies, M R Alexander, J Phys Chem B 113 (2009) 11574
If you require PDF copies of the publications, please contact us below.
Contact: Alex Shard