National Physical Laboratory

Analysing ELISA

NPL's Biotechnology group have been invited to join an international committee to improve medical diagnosis based on a specialised procedure called 'ELISA' (Enzyme Linked ImmunoSorbant Assay).

Analysing ELISA

An ELISA is used to detect certain bio-molecules within our bodies, which are produced either directly from an infection (such as viruses, or bacteria), or released by the body to fight off the infection (such as antibodies). It is also used to detect signs of damage, such as blood clots, that could lead to health problems if left untreated. ELISAs can also be used in clinical testing of drugs based on bio-molecules, such as hormone replacement therapies.

NPL have been working on development, the determination of uncertainty and validation of ELISA techniques for many years, and has established itself as a leader in the field. This reputation has lead to exciting collaborations with two international regulatory bodies for medical diagnostic tests.

NPL has been approached by the United States Pharmacopoeia (USP) to provide an independent study into how well different ELISA procedures measure contaminants in biopharmaceutical products. NPL's recommendations are now forming part of a framework that will set new regulatory guidelines for ELISA.

NPL has also been invited to join a prestigious international committee (linked to the International Federation of Clinical Chemists), which is looking to develop a standard for measurement of a heart attack indicator produced by the body, called Troponin I.

NPL will now work with other international expert labs to develop methods that will enable calibration of Troponin I ELISA to a traceable reference method devised by NPL. This will ensure accurate, robust, and consistent measurement of this substance which could lead medical practitioners towards improved diagnosis of heart conditions.

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Last Updated: 9 May 2014
Created: 13 Aug 2010

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