Higher-order protein structure measurements for biopharmaceutical quality control.
- Author(s):
- Ravi, J, LePevelen, D*, Tranter, G*, Knight, A
- Source:
- NPL Report AS 9, August 2007
- ISSN:
- 1754-2928
- ISBN:
- NPL Doc. Ref:
- PDB: 4729 | DDB: 1571
- Document Type:
- NPL Report
- DOI:
Note: An asterisk after an author's name indicates a non-NPL author.
Abstract:
This report reviews the available techniques for measuring the higher-order structure of proteins, and assesses their suitability for quality control in the biopharmaceutical industry. FTIR is found to be the technique which best compliments CD, currently the dominant technique. We explore measurement issues of FTIR and make best practice recommendations. We also advide that FTIR should be used in combination with CD.
Further Information
General information about NPL publications and details to contact the British Library for other published papers can be found on the NPL Publications Homepage.