Josephine's interests include:
- Mass spectrometry instrument and method development
- Fundamentals of MALDI MS (matrix assisted laser desorption/ionisation mass spectrometry) and ambient mass spectrometry techniques
- Measurement standardisation and data processing tools for mass spectrometry imaging
- Application of mass spectrometry imaging in life sciences and drug discovery
Dr Josephine Bunch is a Principal Scientist and Co-Director of the National Centre of Excellence in Mass Spectrometry Imaging (NiCE-MSI) at NPL and Associate Professor in the School of Pharmacy at the University of Nottingham. At NPL, Josephine leads research and metrology in MALDI and ambient mass spectrometry imaging within NiCE-MSI. Josephine previously led a research group in mass spectrometry imaging at the University of Birmingham, where she was a Lecturer in Chemistry and Imaging in the School of Chemistry and PSIBS Doctoral Training Centre (2009-2013).
Josephine completed a PhD in mass spectrometry imaging at Sheffield Hallam University, sponsored by Pfizer Global R&D (2005). She moved to the University of Sheffield (Department of Chemistry) in 2004 for her postdoctoral appointments (2004-2009). During this time, she was awarded an independent Enterprise Fellowship to support commercialisation of mass spectrometry imaging activities.
Josephine has expertise in a range of mass spectrometry imaging techniques and has published more than 40 articles on mass spectrometry imaging of lipids, drugs, proteins, peptides and metabolites using a range of dedicated mass spectrometry techniques. Josephine's group comprises a multidisciplinary team of physicists, chemists, computer scientists and biomedical scientists. The group host PhD students from the University of Nottingham, the University of Birmingham, Imperial College London and the University of Surrey.
Current projects are funded by the National Measurement System, NC3Rs, EPSRC and Innovate UK, and UK plc.
- Analysis of urine, oral fluid and fingerprints by liquid extraction surface analysis coupled to high resolution MS and MS/MS – opportunities for forensic and biomedical science
Bailey, M., Randall, E.C., Costa, C., Salter, T. L., Race, A.M. de Puit, M., Koeberg, M., Baumert, M. and Bunch J.
Analytical Methods, 2016
- Investigating MALDI MSI parameters (Part 1) - A systematic survey of the effects of repetition rates up to 20 kHz in continuous raster mode
Rory T. Steven, Alex Dexter and Josephine Bunch
- Liquid Extraction Surface Analysis Mass Spectrometry Coupled with Field Asymmetric Waveform Ion Mobility Spectrometry for Analysis of Intact Proteins from Biological Substrates
Sarsby, J., Griffiths, R. L., Race, A. M., Bunch,J., Randall, E. C., Creese, A. J., and Cooper, H. J.
Analytical Chemistry, 87 (13), pp 6794–6800, 2015
- Single-cell Analysis: Visualizing Pharmaceutical and Metabolite Uptake in Cells with Label-free 3D Mass Spectrometry Imaging
Passarelli, M. K., Newman, C. J., Marshall, P. S., West, A., Gilmore, I.S., Bunch, J., Alexander, M.R., Dollery, C.T.
Analytical Chemistry, 2015
- Optimisation of colour schemes to accurately display mass spectrometry imaging data based on human colour perception
Race, A. M., and Bunch, J.
Analytical and Bioanalytical Chemistry, 407 (8), pp 2047-2054, 2015
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