Current Interests

Graham Worsley is currently investigating techniques to improve information content in lateral flow assays, e.g. using spectrally distinguishable nanotags to enable within testline multiplexing capable of quantitative biomarker detection. These tags include fluorescently labelled polystyrene microspheres and SERS distinguishable nanoparticles. His interest with sandwich based assays extends beyond the standard antibody based methods and the Biotechology Group is currently investigating aptamer affinity ligands as alternatives.

Graham has recently developed assays to detect wound and inflammatory biomarkers as part of a successful Technology Strategy Board funded project and the Biotechology Group will soon be trialling the assays in the clinic.

Biography

Graham joined NPL from Smart Holograms (2006-2008) where, as senior scientist in their medical diagnostics division, he developed their novel holographic glucose and pH biosensors. Prior to this, Graham was a member of Solexa Ltd's surface chemistry and integration team (2002-2006). During his time at Solexa, he fulfilled a multidisciplinary role assisting in the optimisation and development of many aspects of the company's DNA sequencing technology, which is now sold by Illumina Inc. following a $600 million buyout of Solexa in 2006. His PhD in Molecular Diagnostics at Cranfield University involved the development of a novel point mutation detection technique based on a solid phase amplification approach with integrated surface plasmon resonance based monitoring.

Selected Publications

• Rapid duplex immunoassay for wound biomarkers at the point of care
  Biosensors and Bioelectronics
• Polymer- and colloid-mediated bioassays, sensors and diagnostics
  A. M. Horgan, J. D. Moore, J. E. Noble, et al
  Trends In Biotechnology, 28 (9), pages 485-494 (2010)
  DOI: 10.1016/j.tibtech.2010.06.006
• Accurate whole human genome sequencing using reversible terminator chemistry
  D. R. Bentley, S. Balasubramanian, et al
  Nature, 456 (7218), pages 53-59 (2008)
  DOI: 10.1038/nature07517
• Measurement of glucose in blood with a phenylboronic acid optical sensor
  G. J. Worsley, G. A. Tourniaire, et al
  J Diabetes Sci. Technol., 2 (2), pages 213-220 (2008)
  PMCID: PMC2771504
• Continuous blood glucose monitoring with a thin-film optical sensor
  G. J. Worsley, G. A. Tourniaire, et al
  Clinical Chemistry, 53 (10), pages 1820-1826 (2007)
  DOI: 10.1373/clinchem.2007.091629
• pH-sensitive holograms for continuous monitoring in plasma
  K. Medlock, H. Harmer, et al
  Analytical and Bioanalytical Chemistry, 389 (5), pages 1533-1539 (2007)
  DOI: 10.1007/s00216-007-1548-9

Contact details

E-mail: graham.worsley@npl.co.uk
Tel: 020 8943 6684