Current Interests

• Protein folding, misfolding and aggregation
• Multi-technique and multi-scale biophysical approaches to protein structure elucidation
• Conformational diagnostics and biomarker detection

Biography

After receiving her Laurea (five year degree) in Chemistry (La Sapienza, Rome) Eleonora worked for a few years in industry (both in QC and drug discovery) before coming to the UK, where she completed her PhD in protein folding with Professor Nicholas Price at the University of Glasgow, and post-doctoral studies in protein design at the University of Sussex. Eleonora joined NPL in 2005, where her main research interests focus on the study of protein structure-function relationships and folding.

Selected Publications

• Membrane Mediated Regulation in Free Peptides of HIV-1 gp41: Minimal Modulation of the Hemifusion Phase
  E. Cerasoli, J. Ravi, C. Gregor, R. Hussain, G. Siligardi, G. Martyna, J. Crain, M. G. Ryadnov
  Phys. Chem. Chem. Phys. 14, pages 1277-1285 (2012)
• Antibody Recognition of a Human Chorionic Gonadotropin Epitope (hCGβ66-80) Depends on Local Structure Retained in the Free Peptide
  C. R. Gregor, E. Cerasoli, J. Schouten, J. Ravi, J. Slootstra, A. Horgan, G. J. Martyna, M. G. Ryadnov, P. Davis, J. Crain
  J. Biol. Chem. 286, pages 25016-25026 (2011)
• FTIR markers of methionine oxidation for early detection of oxidized protein therapeutics
  Ravi J, Hills AE, Cerasoli E, Rakowska PD, Ryadnov MG
  Eur. Biophys. J. 40, pages 339-345 (2011)
• Autonomous folding in the membrane proximal HIV peptide gp41(659-671): pH tuneability at micelle interfaces
  C. R. Gregor, E. Cerasoli, P. R. Tulip, M. G. Ryadnov, G. J. Martyna, J. Crain
  Phys. Chem. Chem. Phys. 13, pages 127-135 (2011)
• MiS-MALDI: microgel-selected detection of protein biomarkers by MALDI-ToF mass spectrometry
  E. Cerasoli, P. D. Rakowska, A. Horgan, J. Ravi, M. Bradley, B. Vincent, M. G. Ryadnov
  Mol. Biosyst. 6, pages 2214-2217 (2010)
• Conformational plasticity in an HIV-1 antibody epitope
  P. R. Tulip, C. R. Gregor, R. Z. Troitzsch, G. J. Martyna, E. Cerasoli, G. Tranter, J. Crain
  J. Phys. Chem. B. 114, pages 7942-7950 (2010)

Contact details

E-mail: eleonora.cerasoli@npl.co.uk
Tel: 020 8943 7044