Current interests

Catherine Clark's research interests are focused on the practical implementation and dosimetric verification of IMRT and rotational radiotherapy. She has also worked in the development of quality assurance in advanced radiotherapy trials and developed a credentialing program for IMRT trials in the UK. She is currently setting up a national audit for the use of rotational therapy in the UK, and has published 20 research papers, 69 conference abstracts and two book chapters on these topics.

Biography

Catharine completed her PhD in Radiation Physics in 1998 at University College London. She then moved to Paris, France where she worked at the Institut Gustave Roussy and then at Stanford University, California, USA. Catharine returned to the UK in 2001 and took up a post at the Royal Marsden. She led the IMRT QA for the first national head and neck IMRT trial and set up the UK IMRT credentialing programme. Catharine has worked in the field of IMRT for the last 10 years and has published widely in this area. She has lectured on IMRT on many national and international courses.

Catharine is currently the chair of the ESTRO 31 meeting Young committee and a member of the Scientific Committee. She is a member of the National Cancer Research Institute Clinical and Translational Radiotherapy Research Working Group (CTRad Workstream 4 – New technology, Physics and Quality Assurance) and the National Radiotherapy Implementation Group IGRT subgroup. Previously she was on the National Cancer Action Team IMRT Tender Evaluation Panel and was also a member of the IPEM RTSIG IMRT Working Party which published IPEM Report 96: Guidance for the Clinical Implementation of Intensity Modulated Radiation Therapy.

Catharine currently holds a joint post at the Royal Surrey Hospital and the National Physical Laboratory.

Selected publications

• Conventional versus hypofractionated high-dose intensity-modulated radiotherapy for prostate cancer: preliminary safety results from the CHHiP randomised controlled trial
  D. Dearnaley, I. Syndikus, G. Sumo, M. Bidmead, D. Bloomfield, C. H. Clark, A. Gao, S. Hassan, A. Horwich, R. Huddart, V. Khoo, P. Kirkbride, H. Mayles, P. Mayles, O. Naismith, C. Parker, H. Patterson, M. Russell, C. Scrase, C. South, J. Staffurth, E. Hall
  The Lancet Oncology (2011)
  doi: 10.1016/S1470-2045(11)70293-5
• Volumetric Modulated Arc Therapy: a review of current literature and clinical use in practice
  M. Teoh, C. H. Clark, K. Wood, S. Whitaker and A. Nisbet
  The British Journal of Radiology 84, pages 967-996 (2011)
• Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial
  C. M. Nutting, J. P. Morden, K. J. Harringtom, M. T. Guerrero Urbano, S. A. Bhide, C. H. Clark, E. A. Miles, A. B. Miah, K. Newbold, M. A. Tanay, F. Adab, S. J. Jefferies, C. Scrase, B. K. Yap, R. P. A'Hern, M. A. Sydenham, M. Emson, E. Hall on behalf of the PARSPORT trial management group
  Lancet Oncol. 12 (2), pages 127-136 (2011)
• Dose-Escalated Intensity-Modulated Radiotherapy Is Feasible and May Improve Locoregional Control and Laryngeal Preservation in Laryngo-hypopharyngeal Cancers
  A. B. Miah, S. A. Bhide, M. T. Guerrero-Urbano, C. H. Clark, A. M. Bidmead, S. St Rose, Y. Barbachano, R. A'hern, M. Tanay, J. Hickey, R. Nicol, K. L. Newbold, K. J. Harrington, C. M. Nutting
  Int. J. Radiat. Oncol. Biol. Phys. 82 (2), pages 539-47 (2012)
• Dosimetry audit for a multi-centre IMRT head and neck trial
  C. H. Clark, V. N. Hansen, H. Chantler, C. Edwards, H. V. James, G. Webster, E. A. Miles, M. T. Guerrero-Urbano, S. A. Bhide, A. M. Bidmead, C. M. Nutting
  Radiother Oncol. 93 (1), pages 102-8 (2009)
• Pre-trial quality assurance processes for an IMRT trial: PARSPORT, a UK multi-centre phase III trial comparing conventional radiotherapy and parotid sparing IMRT for locally advanced head and neck cancer
  C. H. Clark, E. A. Miles, M. T. Guerrero-Urbano, S. A. Bhide, A. M. Bidmead, K. J. Harrington, C. M.  Nutting
  Br J Radiol. 82 (979) pages 585-94 (2009)
• Intensity Modulated Radiotherapy (IMRT) in locally advanced thyroid cancer: Acute toxicity results of a phase I study
  M. T. Guerrero-Urbano, C. H. Clark, V. N. Hansen, E. J. Adams, E. A. Miles, H. McNair, A. M. Bidmead, J. Warrington, D. P. Dearnaley, C. Harmer, K. J. Harrington, C. M. Nutting
  Radiother Oncol. 85 (1), pages 58-63 (2007)
• Intensity modulated radiotherapy improves target coverage and parotid gland sparing when delivering total mucosal irradiation in patients with squamous cell carcinoma of head and neck of unknown primary site
  S. Bhide, C. H. Clark, K. J. Harrington, C. M. Nutting
  Med Dosim. 32 (3), pages 188-95 (2007)
• A phase I study of dose-escalated chemoradiation with accelerated intensity modulated radiotherapy in locally advanced head and neck cancer
  T. Guerrero Urbano, C. H. Clark, V. N. Hansen, E. J. Adams, R. A'hern, E. A. Miles, H. McNair, M. Bidmead, A. P. Warrington, D. P. Dearnaley, K. J. Harrington, C. M. Nutting
  Radiother Oncol. 85 (1), pages 36-41 (2007)

Invited presentations

• To PhD or not to PhD, that is the question - ESTRO May 2011
• Dosimetric uncertainty in clinical practice - UKRO April 2011
• Problems and Pitfalls of IMRT verification - BIR Expansion of IMRT meeting Feb 2011
• IMRT credentialing - Varian Users Group Oct 08
• IMRT credentialing in the UK - IPEM ASM Sept 2008
• IMRT credentialing in the UK - North London Cancer Network June 2008
• IMRT implementation: From a single centre to a national trial - IPEM IMRT meeting July 2005

Contact details

E-mail: catharine.clark@npl.co.uk
Tel: 020 8943 6329