National Physical Laboratory

Ian Gilmore appointed Senior NPL Fellow

Professor Ian Gilmore has been appointed a Senior NPL Fellow for landmark achievements in measurement of the location, identity and function of molecules at the nano- and micro-scales using mass spectrometry.

Ian Gilmore, Senior Fellow

Ian founded the UK's National Centre of Excellence in Mass Spectrometry Imaging (NiCE-MSI) at NPL in 2012, to support the development, understanding and application of these powerful analytical techniques. Today, NiCE-MSI provides a measurement framework which ensures reproducible measurements, meets emerging needs in industry and academia, supports uptake and provides training for the next generation of researchers. He has pioneered advances in physical metrology to support the life sciences.

Ian's research is highly interdisciplinary and collaborative. A key example is his work with GlaxoSmithKline, supporting the pharmaceutical industry in its quest to reduce late-stage drug failure. Measurements that can identify future failure at the early stages of drug development are of great importance. A major focus of his research is the label-free imaging of the distribution of pharmaceutical compounds and metabolites with sub-cellular resolution. The insights provided could answer long-standing questions about whether drug concentrations are sufficiently high in the right places to have a therapeutic effect, or if a medicine is lodging within cellular components and causing toxicity.

To address this measurement challenge, Ian conceived a revolutionary new instrument for 3D imaging at the sub-cellular level, the NPL 3D OrbiSIMS, developed in collaboration with GlaxoSmithKline, ION-TOF GmbH, Thermo Fisher Scientific and the University of Nottingham. The instrument, currently the only one of its kind in the world, has a flagship role in the NPL-led Cancer Research UK Grand Challenge project and will have a major impact in the life sciences, as well as in advanced manufacturing in the study of 2D materials and buried interfaces.

Ian has a leading role in international standardisation as Chair of the ISO Subcommittee for Secondary Ion Mass Spectrometry (ISO/TC 201/SC 6) and the VAMAS Technical Working Area for Surface Chemical Analysis (TWA 2). He is widely recognised for his international leadership and support to the community.

Find out more about the National Centre of Excellence in Mass Spectrometry Imaging at NPL.

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Last Updated: 3 May 2017
Created: 3 May 2017

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