National Physical Laboratory

Label free antibody pairing and analysis of monoclonal antibody epitope specificity

Epitope mapping 

Measuring the epitope specificity of a panel of mAbs is an important step in fully characterising and selecting the best therapeutic candidate during drug development. NPL is able to offer epitope mapping using its Biacore T100 platform, which offers significant advantages over more traditional test methods such as ELISA and RIA:

  • All stages of the binding process of multiple mAbs is followed in real time

  • The mAbs do not necessarily require purification before analysis and they do not need to be labelled

  • Assay time is short and numerous analyses can be performed automatically


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Last Updated: 18 Aug 2015
Created: 6 May 2009


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