National Physical Laboratory

Real-time imaging of filamentous protein self assembly by structured illumination and TIRF microscopy

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Published: 19 July 2016

Authors: Michael Shaw, Angelo Bella, Santanu Ray and Maxim Ryadnov

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Many proteins are known to form filamentous structures, which have varied biological and pathological functions. Examples are:

  • cytoskeletal proteins (actin filaments, intermediate filaments and microtubules) that mediate cell adhesion, migration and proliferation;
  • amyloid fibrils which underpin neurodegenerative disorders such as Alzheimer's, Huntington's and Parkinson's diseases;
  • extracellular matrices that support all cellular processes
  • filamentous viruses whose capsids are thought to assemble through a similar mechanism.

Last Updated: 19 Jul 2016
Created: 19 Jul 2016

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